Publications by authors named "Kent W Nowels"
Purpose: To identify morphologic and dynamic enhancement magnetic resonance imaging (MRI) features of pure ductal carcinoma in situ (DCIS) by using a new intensity-modulated parametric mapping technique, and to correlate the MRI features with histopathologic findings.
Materials And Methods: Fourteen patients with pure DCIS on pathology underwent conventional mammography and contrast-enhanced (CE) MRI using the intensity-modulated parametric mapping technique. The MR images were reviewed and the lesions were categorized according to morphologic and kinetic criteria from the ACR BI-RADS-MRI Lexicon, with BI-RADS 4 and 5 lesions classified as suspicious.
Objective: Nipple fluid production and atypical breast duct cells in women at high risk of breast cancer have been associated with further increased risk. Most publications on ductal lavage for cell collection report cannulating fluid-yielding ducts only. We report lavage of fluid-yielding and non-fluid-yielding ducts in women at high inherited breast cancer risk.
View Article and Find Full Text PDFBackground: We performed this study to determine rates of close or transected cancer margins after magnetic resonance imaging-guided bracket wire localization for nonpalpable breast lesions.
Study Design: Of 243 women undergoing MRI-guided wire localizations, 26 had MRI bracket wire localization to excise either a known cancer (n = 19) or a suspicious MRI-detected lesion (n = 7). We reviewed patient age, preoperative diagnosis, operative intent, mammographic breast density, MRI lesion size, MRI enhancement curve and morphology, MRI Breast Imaging Reporting and Data System (BI-RADS) assessment code, number of bracket wires, and pathology size.
Article Synopsis
- IDC and ILC are the two main types of breast cancer, with ILC rapidly increasing in incidence, particularly in the U.S. and Western Europe.
- Comprehensive gene expression profiling was conducted using RNA from various ILCs, IDCs, and normal tissues, revealing distinct gene expression patterns between the two cancer types.
- Over half of the typical ILCs showed different transcription programs from IDCs, indicating potential differences in treatment approaches; further research is needed to fully understand these variations and their clinical implications.
Background: Intensive screening is an alternative to prophylactic mastectomy in women at high risk for developing breast carcinoma. The current article reports preliminary results from a screening protocol using high-quality magnetic resonance imaging (MRI), ductal lavage (DL), clinical breast examination, and mammography to identify early malignancy and high-risk lesions in women at increased genetic risk of breast carcinoma.
Methods: Women with inherited BRCA1 or BRCA2 mutations or women with a >10% risk of developing breast carcinoma at 10 years, as estimated by the Claus model, were eligible.
Article Synopsis
- A study reviewed breast MRI images from 15 patients with pathologically confirmed intraductal papillomas to describe their appearance using advanced MRI techniques.
- The research identified three distinct patterns of papillomas: small, smooth masses related to duct enlargement, irregular masses found in patients without discharge, and some that were not visible on imaging.
- Some papillomas exhibited features that could easily be misinterpreted as invasive cancer, highlighting the variability in their MRI appearance and the challenges in diagnosis.
Background: Dissemination of tumor cells from needle biopsy has been observed in a wide range of tumor types. Fine needle aspiration (FNA) biopsy has become accepted as the first-line test in the evaluation of thyroid nodules. Local recurrence of thyroid cancer from needle track seeding is an extremely rare complication of thyroid FNA.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how dynamic contrast-enhanced MRI images of infiltrating lobular carcinoma in the breast relate to the actual tissue pathology findings.
- Thirteen cases were analyzed from women diagnosed with infiltrating lobular carcinoma, observing MR imaging patterns and comparing them with histopathological results.
- Three distinct imaging patterns were identified: solitary masses with irregular margins, multiple lesions (connected or separated), and enhancing septa, all of which correspond to specific tumor characteristics found in pathology, suggesting that MRI can effectively detect this type of cancer.