Biomechanical Evaluation of Different Plate Configurations for Midshaft Clavicle Fracture Fixation: Single Plating Compared with Dual Mini-Fragment Plating.

Background: Dual-plate constructs have become an increasingly common fixation technique for midshaft clavicle fractures and typically involve the use of mini-fragment plates. The goal of this technique is to reduce plate prominence and implant irritation. However, limited biomechanical data exist for these lower-profile constructs.

Residual substance P levels after capsaicin treatment correlate with tendon repair.

The aim of the study was to assess healing after capsaicin-induced substance P (SP) depletion during rat Achilles tendon repair by biomechanical testing. Capsaicin treatment reduced the concentrations of SP by ∼60% and calcitonin gene-related peptide by ∼40% as compared with the control group, as assessed by radioimmunoassay in the dorsal root ganglia, at 1 and 4 weeks post-tendon rupture. Also, the peripheral neuronal presence of SP and calcitonin gene-related peptide, as assessed by immunohistochemistry, was lower at both weeks 1 and 4.

Nerve growth factor improves ligament healing.

Previous work has shown that innervation participates in normal ligament healing. The present study was performed to determine if exogenous nerve growth factor (NGF) would improve the healing of injured ligament by promoting reinnervation, blood flow, and angiogenesis. Two groups of 30 Sprague-Dawley rats underwent unilateral medial collateral ligament transection (MCL).

A potential animal model for creating a controlled and reversible anterior cruciate ligament insufficiency.

We developed and tested a device to manipulate the axial position of the tibial anterior cruciate ligament (ACL) insertion in vitro to create a potential animal model that could simulate both ACL insufficiency and 'optimal' ACL reconstruction. This model is based on the concept that controlled incremental proximal displacement of the tibial ACL insertion simulates ACL insufficiency. Replacing the insertion at the joint level and then adjusting its position until the forces recorded equaled those in the ACL-intact knee can simulate 'optimal' ACL reconstruction.