Publications by authors named "Kent Mok"
Article Synopsis
- - This report details a pediatric case of MPPH syndrome, a rare neurodevelopmental disorder linked to gene variants, specifically a unique CCND2 variant in this patient that caused serious neurological issues.
- - The patient showed significant prenatal abnormalities, such as ventriculomegaly and polymicrogyria, and developed infantile spasms which were eventually managed with topiramate after prednisone failed.
- - The findings emphasize the need for prompt genetic testing and neuroimaging for accurate diagnosis and management of MPPH syndrome, suggesting that early intervention could lead to better developmental outcomes.
Gaining independent genetic access to discrete cell types is critical to interrogate their biological functions as well as to deliver precise gene therapy. Transcriptomics has allowed us to profile cell populations with extraordinary precision, revealing that cell types are typically defined by a unique combination of genetic markers. Given the lack of adequate tools to target cell types based on multiple markers, most cell types remain inaccessible to genetic manipulation.
View Article and Find Full Text PDFBuilding a sizable, complex brain requires both cellular expansion and diversification. One mechanism to achieve these goals is production of multiple transiently amplifying intermediate neural progenitors (INPs) from a single neural stem cell. Like mammalian neural stem cells, Drosophila type II neuroblasts utilize INPs to produce neurons and glia.
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