Publications by authors named "Kenny Bossens"
Introduction: Chiari-like malformation (CM) and syringomyelia (SM) are frequently diagnosed conditions in small and toy dog breeds, such as the Cavalier King Charles Spaniel and Griffon Bruxellois. CM/SM is only rarely reported in Pomeranians in literature to date. The aims of this study are to 1/describe the phenotype of Pomeranians with or without CM/SM and 2/evaluate for differences and associations between CM/SM and owner-reported clinical signs (ORCS) or signalment factors.
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- The study focuses on the genetic relationship between KCNJ10 and CAPN1 variants and conditions like spinocerebellar ataxia, myokymia, and neuromyotonia in dogs.
- The research analyzed 33 dogs with various combinations of these signs, specifically looking for specific genetic variants linked to these conditions.
- Results showed a strong association between the KCNJ10 variant and spinocerebellar ataxia, while the CAPN1 variant was less common; however, dogs with myokymia and neuromyotonia did not exhibit these variants, suggesting further investigation is needed for other potential causes.
Background: Some paroxysmal movement disorders remain without an identified genetic cause.
Objectives: The aim was to identify the causal genetic variant for a paroxysmal dystonia-ataxia syndrome in Weimaraner dogs.
Methods: Clinical and diagnostic investigations were performed.
Background Context: In canine intervertebral disc (IVD) disease, a useful animal model, only little is known about the inflammatory response in the epidural space.
Purpose: To determine messenger RNA (mRNA) expressions of selected cytokines, chemokines, and matrix metalloproteinases (MMPs) qualitatively and semiquantitatively over the course of the disease and to correlate results to neurologic status and outcome.
Study Design/setting: Prospective study using extruded IVD material of dogs with thoracolumbar IVD extrusion.