Publications by authors named "Kenney Lenz"
PrP lowering is effective against prion disease in animal models and is being tested clinically. Therapies in the current pipeline lower PrP production, leaving pre-existing PrP to be cleared according to its own half-life. We hypothesized that PrP's half-life may be a rate-limiting factor for the time to effect of PrP-lowering drugs, and one reason why late treatment of prion-infected mice is not as effective as early treatment.
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- Prion diseases happen when a special protein in the brain gets twisted wrong, which can cause serious memory problems and even death.
- Researchers created something called CHARM, a tool that can change how our DNA works to stop these bad proteins from causing harm.
- In tests with mice, CHARM successfully turned off the harmful protein in their brains and could help treat other brain diseases too!