Mononuclear, hexanuclear and polymeric indium(III) pyrazolido complexes; structural characterization, dynamic solution studies and luminescent properties.

A new family of six mononuclear indium(III) complexes of formula -[InCl(pz*H)]-pz*H = pyrazole (pzH), or substituted pyrazoles: 4-Cl-pzH, 4-Br-pzH, 4-I-pzH, 4-Ph-pzH and 3,5-Me-pzH-were synthesized by addition reactions of InCl and pz*H and crystallographically characterized. The fluxional behaviour of the complexes, probed by variable temperature H NMR spectroscopy in the 328 K to 173 K range, was attributed to (at least) four simultaneous processes: pyrazole N-H proton dissociation/association, /-pyrazole exchange, and N/N tautomerization of the - and of the -pyrazoles. Three novel trianionic hexanuclear complexes of general formula (pipH)[InCl(μ-OH)(μ-OH)(μ-pz*)]-pz* = pz, 4-Cl-pz and 4-Ph-pz-showing μ-hydroxo and μ-oxo bridges were synthesized from the corresponding -[InCl(pz*H)] and characterized by single crystal X-ray diffraction and H NMR.

Expanding the Therapeutic Potential of the Iron Chelator Deferasirox in the Development of Aqueous Stable Ti(IV) Anticancer Complexes.

The recent X-ray structure of titanium(IV)-bound human serum transferrin (STf) exhibiting citrate as a synergistic anion reveals a difference in Ti(IV) coordination versus iron(III), the metal endogenously delivered by the protein to cells. This finding enriches our bioinspired drug design strategy for Ti(IV)-based anticancer therapeutics, which applies a family of Fe(III) chelators termed chemical transferrin mimetic (cTfm) ligands to inhibit Fe bioavailability in cancer cells. Deferasirox, a drug used for iron overload disease, is a cTfm ligand that models STf coordination to Fe(III), favoring Fe(III) binding versus Ti(IV).

(E)-1-Ferrocenyl-3-(2-meth-oxy-phen-yl)prop-2-en-1-one.

The structure of the title compound, [Fe(C5H5)(C15H13O2)], consists of a ferrocenyl moiety and a 2-meth-oxy-phenyl group linked through a prop-2-en-1-one spacer in an E conformation. In the ferrocene unit, the substituted cyclo-penta-dienyl (Cps) ring and the unsubstituted cyclo-penta-dienyl ring (Cp) are almost parallel to one another [dihedral angle = 1.78 (14)°], and the Cp and Cps rings are in a gauche conformation.