Publications by authors named "Kenneth Teel"
Article Synopsis
- The retina needs a lot of energy, and it gets this energy from a process called aerobic glycolysis, where lactate dehydrogenase A (LDHA) plays an important role by turning pyruvate into lactate.
- Researchers found that LDHA is mostly found in rods and cones (the light-sensing cells), while another form, LDHB, is found in other types of retinal cells.
- When they removed LDHA from the retina in mice, it hurt their vision and messed up the structure, but not having LDHA in supporting cells didn't affect their sight, showing LDHA is crucial for a healthy retina.
Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 has been reported to cause deafness, mental retardation, postnatal growth failure, and microcephaly. IGF-1R is expressed in the retina and photoreceptor neurons; however, its functional role is not known.
View Article and Find Full Text PDFRibosomal targeting strategy and nuclear labeling to analyze photoreceptor phosphoinositide signatures.
Biochim Biophys Acta Mol Cell Biol Lipids
August 2022
Article Synopsis
- The study looks at special molecules called phosphoinositides (PIPs) in cells responsible for vision in the retina, called rod photoreceptors.
- Researchers used a special technique to tag certain proteins and analyze which PIPs are found in these rod cells.
- The results showed that many important enzymes related to PIPs are more active in rod cells than in other parts of the retina, and this research could help in understanding how these cells work better.
The retinal pigmented epithelium (RPE) is a monolayer of multifunctional cells located at the back of the eye. High membrane turnover and polarization, including formation of actin-based apical microvilli, are essential for RPE function and retinal health. Herein, we demonstrate an important role for βA3/A1-crystallin in RPE.
View Article and Find Full Text PDFProtein tyrosine kinases and protein phosphatases play a critical role in cellular regulation. The length of a cellular response depends on the interplay between activating protein kinases and deactivating protein phosphatases. Protein tyrosine phosphatase 1B (PTP1B) and growth factor receptor-bound protein 14 (Grb14) are negative regulators of receptor tyrosine kinases.
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