Compact Electrochromic Optical Recording of Bioelectric Potentials.

Electrochromic optical recording (ECORE) is a label-free method that utilizes electrochromism to optically detect electrical signals in biological cells with a high signal-to-noise ratio and is suitable for long-term recording. However, ECORE usually requires a large and intricate optical setup, making it relatively difficult to transport and to study specimens on a large scale. Here, we present a Compact ECORE (CECORE) apparatus that drastically reduces the spatial footprint and complexity of the ECORE setup whilst maintaining high sensitivity.

Dual-Color Optical Recording of Bioelectric Potentials by Polymer Electrochromism.

Optical recording based on voltage-sensitive fluorescent reporters allows for spatial flexibility of measuring from desired cells, but photobleaching and phototoxicity of the fluorescent labels often limit their sensitivity and recording duration. Voltage-dependent optical absorption, rather than fluorescence, of electrochromic materials, would overcome these limitations to achieve long-term optical recording of bioelectrical signals. Electrochromic materials such as PEDOT:PSS possess the property that an applied voltage can either increase or decrease the light absorption depending on the wavelength.

The effect of dynamic intermittent hypoxic conditioning on arterial oxygen saturation.

Background: Increases in arterial oxygen saturation (SaO2) in response to intermittent hypoxic exposure (IHE) are well established. However, IHE protocols have historically involved static hypoxic environments. The effect of a dynamic hypoxic environment on SaO2 is not known.

Selective serotonin reuptake inhibitors and rhabdomyolysis after eccentric exercise.

Purpose: The purpose of this report was to review three cases of clinically significant rhabdomyolysis that developed in research subjects after completing an eccentric exercise protocol. All three cases occurred in subjects who reported use of selective serotonin reuptake inhibitors (SSRI).

Methods: Sixty-three subjects enrolled in the study.

Physiologic considerations of therapeutic slideboard rehabilitation with an external loading device.

Context: Slideboard exercise is consistent with the American College of Sports Medicine guidelines for exercise intensity of 55% to 90% of maximal heart rate or 40% to 85% of maximal oxygen uptake.

Objective: To determine if slideboard exercise while in a leg harness increases the metabolic and cardiorespiratory demands.

Design: Repeated-measures design.