Improving survival of retinoblastoma in Uganda.

Background: Diagnostic delay results in relatively high mortality among children with retinoblastoma in Uganda, where treatment was limited to surgery and, for some, radiotherapy. In order to improve outcomes, a simple programme of neoadjuvant and adjuvant chemotherapy was introduced. Here we report survival before and after this change to medical practice.

Clinical features and survival among children with retinoblastoma in Uganda.

Aims: To characterise the clinical features, treatment and outcome of children diagnosed with retinoblastoma in Uganda.

Methods: The study comprised a 6-year nationwide enrolment with follow-up.

Results: In total, 282 cases were enrolled, 26% (72) were bilateral; 6% were lost to follow-up.

Ethnic and mouse strain differences in central corneal thickness and association with pigmentation phenotype.

The cornea is a transparent structure that permits the refraction of light into the eye. Evidence from a range of studies indicates that central corneal thickness (CCT) is strongly genetically determined. Support for a genetic component comes from data showing significant variation in CCT between different human ethnic groups.