Publications by authors named "Kenneth J Henry"
An arylsulfonamide that targets cell wall biosynthesis in .
Antimicrob Agents Chemother
November 2024
Article Synopsis
- - We synthesized a new arylsulfonamide that showed effectiveness against both extracellular and intracellular bacilli, while also displaying selectivity in its action against HepG2 cells.
- - The drug disrupts bacterial cell wall synthesis, likely targeting the MmpL3 protein, which is known to export mycolic acids necessary for the bacterial cell wall.
- - A specific mutation in the MmpL3 protein led to some resistance against the drug, further supporting the idea that MmpL3 is the main target of the compound's action.
Background: Animal and clinical studies have revealed that focal peripheral nerve axon demyelination is accompanied by nociceptive pain behavior. C-C and C-X-C chemokines and their receptors have been strongly implicated in demyelinating polyneuropathies and persistent pain syndromes. Herein, we studied the degree to which chronic nociceptive pain behavior is correlated with the neuronal expression of chemokines and their receptors following unilateral lysophosphatidylcholine (LPC)-induced focal demyelination of the sciatic nerve in rats.
View Article and Find Full Text PDF