Publications by authors named "Kenneth Iain Cumming"
Pharm Dev Technol
March 2016
Article Synopsis
- - The study investigates how heat affects the structural stability of Polyethylene oxide (PEO) in direct compression tablets, particularly in relation to drug release properties and filler solubility.
- - Results showed that soluble fillers like lactose enhanced drug release for highly water-soluble drugs like propranolol HCl, while insoluble fillers like dicalcium phosphate (DCP) provided a more stable release.
- - The hydration characteristics of the fillers significantly influenced drug release rates across different PEO molecular weights and varying drug solubilities, with notable differences observed for the partially soluble drug theophylline over time.
