Publications by authors named "Kenneth Flack"
MicroRNAs (miRNAs) are stably present in circulatory systems. They are bound to various carriers like proteins, lipoprotein particles, and exosomes. Investigating the process of miRNA distribution among these carriers will help improve our understanding of their functions in the extracellular environment and their potential relationship with diseases.
View Article and Find Full Text PDFCirculating microRNAs (miRNAs) are potential biomarkers useful in cancer diagnosis. They have been found to be bound to various carriers like proteins, lipoprotein particles, and exosomes. It is likely that only miRNAs in particular carriers, but not the overall quantity, are directly related to cancer development.
View Article and Find Full Text PDFA new method to label and detect the long ssDNA products from rolling circle (RC) amplification was reported. ZnS nanocrystal clusters (NCCs) were used to tag the RC products. The NCCs release millions of cations to trigger millions of metal-responsive dyes for cascade signal amplification.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on improving the extraction and detection of small RNAs using a new low-cost, efficient multi-well/multi-channel (M&M) chip design.
- The M&M chip automates the isolation of small RNAs from cell samples through solid-phase extraction and converts them to stable cDNAs for further analysis in just 15 minutes.
- It allows for the selective enrichment of small RNAs, enabling parallel processing of multiple samples and facilitating simultaneous detection of specific microRNAs, making it an effective tool for studying small RNA expression in limited cells.