Publications by authors named "Kenneth Chibuzor Ofokansi"
Article Synopsis
- * Preventive measures, such as social distancing and mask-wearing, have helped slow the virus's spread; however, the persistent nature of the virus and its variants makes complete eradication difficult.
- * The development of effective vaccines relies heavily on nanotechnology, which enhances vaccine delivery and efficacy; currently, four vaccines are approved for use, with more in progress.
Intranasal artesunate-loaded nanostructured lipid carriers: A convenient alternative to parenteral formulations for the treatment of severe and cerebral malaria.
J Control Release
June 2021
Early treatment with parenteral antimalarials is key in preventing deaths and complications associated with severe and cerebral malaria. This can be challenging in 'hard-to-reach' areas in Africa where transit time to hospitals with facilities to administer drugs parenterally can be more than 6 h. Consequently, the World Health Organization has recommended the use of artesunate (ATS) suppositories for emergency treatment of patients, however, this treatment is only for children under 6 years.
View Article and Find Full Text PDFColon-targeted drug delivery systems (CTDDSs) could be useful for local treatment of inflammatory bowel diseases (IBDs). In this study, various interpolyelectrolyte complexes (IPECs), formed between Eudragit RL100 (EL) and chitosan (CS), by nonstoichiometric method, and tablets based on the IPECs, prepared by wet granulation, were evaluated as potential oral CTDDSs for ibuprofen (IBF). Results obtained showed that the tablets conformed to compendial requirements for acceptance and that CS and EL formed IPECs that showed pH-dependent swelling properties and prolonged the in vitro release of IBF from the tablets in the following descending order: 3 : 2 > 2 : 3 > 1 : 1 ratios of CS and EL.
View Article and Find Full Text PDFArticle Synopsis
- Researchers extracted soluble mucus glycoprotein (S-mucin) from pig intestines and combined it with type B gelatin to create cefaclor-loaded microspheres, using emulsification and crosslinking methods.
- The microspheres showed strong mucoadhesive properties, with cefaclor release being significantly higher and quicker in simulated gastric fluid compared to simulated intestinal fluid, and more effective when mixed with S-mucin.
- The study suggests that the rectal route for delivering cefaclor could be a viable alternative to oral administration, and that careful formulation can lead to targeted delivery to the small intestine, enhancing the drug's bioavailability.