A dual role for A-type lamins in DNA double-strand break repair.

A-type lamins are emerging as regulators of nuclear organization and function. Changes in their expression are associated with cancer and mutations are linked to degenerative diseases -laminopathies-. Although a correlation exists between alterations in lamins and genomic instability, the molecular mechanisms remain largely unknown.

A novel PET tumor delineation method based on adaptive region-growing and dual-front active contours.

To more accurately and precisely delineate a tumor in a 3D PET image, we proposed a novel, semi-automatic, two-stage method by utilizing an adaptive region-growing algorithm and a dual-front active contour model. First, a rough region of interest (ROI) is manually drawn by a radiation oncologist that encloses a tumor. The voxel having the highest intensity in the ROI is chosen as a seed point.

Combined intensity-modulated radiation therapy and brachytherapy in the treatment of cervical cancer.

Purpose: This treatment planning study compared pseudo-step-wedge intensity modulation (PSWIM), intensity-modulated radiation therapy (IMRT), and conventional external irradiation, all combined with brachytherapy, for treatment of patients with cervical cancer.

Methods And Materials: This was a prospective study of 10 patients treated with PSWIM delivering 50.4 Gy to the pelvic lymph nodes and 20 Gy to the cervical tumor.

18F-FDG PET definition of gross tumor volume for radiotherapy of non-small cell lung cancer: is a single standardized uptake value threshold approach appropriate?

Unlabelled: PET with (18)F-FDG has been used in radiation treatment planning for non-small cell lung cancer (NSCLC). Thresholds of 15%-50% the maximum standardized uptake value (SUV(max)) have been used for gross tumor volume (GTV) delineation by PET (PET(GTV)), with 40% being the most commonly used value. Recent studies indicated that 15%-20% may be more appropriate.