Systematic review of MRI findings in children with developmental delay or cognitive impairment.

Aim: To summarize the reported rates of magnetic resonance imaging (MRI) abnormalities in children with isolated global developmental delay (GDD) or intellectual disability (ID).

Method: A literature search was conducted using electronic databases for studies reporting the rate of MRI abnormalities in children with clinically diagnosed ID or GDD and no other neurological signs, symptoms, or previously determined aetiology. All investigations with participants from birth to 18years were considered.

Familial Congenital Facial Synkinesis Due to 12q Duplication: A Case Report and Literature Review.

Inverse Marcus Gunn phenomenon is a rare form of congenital facial synkinesis in which jaw movement temporarily elicits ptosis, either unilateral or bilateral. This phenomenon is presumed to result from dysinnervation of facial muscles during development of the nervous system. We describe 2 brothers, both with inverse Marcus Gunn phenomenon in the context of multiple other congenital anomalies, all presumed secondary to a chromosomal abnormality involving 12q duplication and 1p36 deletion.

Preadolescent indomethacin-responsive headaches without autonomic symptoms.

Objective: A small case series is presented of preadolescent patients with indomethacin-responsive headache.

Background: Preadolescent indomethacin-responsive headache is a rare and poorly understood entity, with few published cases in the literature.

Results: Two young children had similar presentations of indomethacin-responsive headaches.