Radiologist Engagement as a Potential Barrier to the Clinical Translation of Quantitative Imaging for the Assessment of Tumor Heterogeneity.

Rationale And Objective: This study aims to identify potential barriers to the clinical implementation of quantitative imaging for the assessment of tumor heterogeneity.

Materials And Methods: An 18-month prospective observational study was undertaken in which the clinical implementation of computed tomography texture analysis (CTTA) as a technique for quantifying tumor heterogeneity in patients with non-small cell lung cancer was assessed using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework.

Results: Adopters of the technology comprised five specialists with dual accreditation in radiology and nuclear medicine supervising two trainees.

Stakeholder perspectives on the use of positron emission tomography in phase III oncology trials in the UK.

Aim: To identify factors that influence the use of PET in phase III oncology trials in the UK by evaluating stakeholder perspectives.

Methods: A wide range of UK PET research stakeholders with a potential interest in the use of PET in phase III trials were identified and invited to participate. These UK PET research stakeholders were consulted using a semistructured questionnaire on their personal experience with and involvement in PET research, the role of PET in phase III oncology clinical trials and on the promotion of UK PET research and unmet clinical needs in oncology.