Publications by authors named "Kenneth A Livingston"
Background: Postoperative groin complication is a common cause of morbidity in vascular surgery. Prophylactic wound adjuncts addressing this issue have been shown to reduce complications in high-risk patients, but their widespread implementation is limited by their high cost. This study introduces a risk prediction model for patients at a high risk for groin complication which can be accessed through the iPhone application, Vasculink.
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- - Mitochondria play a vital role in respiration and are particularly important in the liver for processes like gluconeogenesis, but during nonalcoholic fatty liver disease (NAFLD), they can produce reactive oxygen species (ROS) that harm liver cells and contribute to inflammation and insulin resistance.
- - Studies in mice showed that increased fatty acid delivery led to greater oxidative metabolism, which in turn elevated stress and inflammation, while knockout of a specific enzyme (Pck1) reduced these negative effects, indicating a strong link between metabolic processes and oxidative damage.
- - Using metformin to lower oxidative metabolism in the liver normalized the associated anabolic pathways and reduced inflammation, linking oxidative stress in human NAFLD cases to metabolic changes from high