Publications by authors named "Kenneth A Crawford"
Article Synopsis
- Ewing sarcoma (EWS) is a type of aggressive tumor that typically affects young people but can occur at any age, and treatment options are limited for cases that recur after initial therapy.
- Recent trials testing different chemotherapy combinations have not led to better survival rates for EWS patients, highlighting a gap in effective treatments.
- Researchers have found that two drugs, enoxacin (an approved antibiotic) and entinostat (not yet approved), show promise as adjuvant therapies alongside chemotherapy, particularly recommending further study on enoxacin for EWS patients.
Article Synopsis
- Metastatic epithelioid sarcoma (EPS) is a serious health issue for kids and young adults, and current treatments like the drug tazemetostat aren't fully effective.
- Scientists studied cancer samples from patients to find weak points in the disease and used advanced technology to help identify potential treatments.
- They discovered that there are important differences between EPS in younger patients and older ones, which suggests that doctors should treat them as separate types of the disease.
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and phenocopies a muscle precursor that fails to undergo terminal differentiation. The alveolar subtype (ARMS) has the poorest prognosis and represents the greatest unmet medical need for RMS. Emerging evidence supports the role of epigenetic dysregulation in RMS.
View Article and Find Full Text PDFFunctional impact of a germline RET mutation in alveolar rhabdomyosarcoma.
Cold Spring Harb Mol Case Stud
June 2021
Specific mutations in the proto-oncogene are associated with multiple endocrine neoplasia type 2A, a hereditary syndrome characterized by tumorigenesis in multiple glandular elements. In rare instances, MEN2A-associated germline mutations have also occurred with non-MEN2A associated cancers. One such germline mutant mutation occurred concomitantly in a young adult diagnosed with alveolar rhabdomyosarcoma, a pediatric and young adult soft-tissue cancer with a generally poor prognosis.
View Article and Find Full Text PDFCase report for an adolescent with germline RET mutation and alveolar rhabdomyosarcoma.
Cold Spring Harb Mol Case Stud
June 2020
In this case report we evaluate the genetics of and scientific basis of therapeutic options for a 14-yr-old male patient diagnosed with metastatic PAX3-FOXO1 fusion positive alveolar rhabdomyosarcoma. A distinguishing genetic feature of this patient was a germline RET C634F mutation, which is a known driver of multiple endocrine neoplasia type 2A (MEN2A) cancer. Through sequential DNA and RNA sequencing analyses over the patient's clinical course, a set of gene mutations, amplifications, and overexpressed genes were identified and biological hypotheses generated to explore the biology of RET and coexisting signaling pathways in rhabdomyosarcoma.
View Article and Find Full Text PDFUndifferentiated small round cell sarcoma in a young male: a case report.
Cold Spring Harb Mol Case Stud
February 2020
-rearranged sarcomas (CRSs) have recently been characterized as a distinct sarcoma subgroup with a less favorable prognosis compared to other small round cell sarcomas. CRSs share morphologic features with Ewing's sarcoma and prior to 2013 were grouped under undifferentiated sarcomas with round cell phenotype by the WHO classification. In this report, whole-genome sequencing and RNA sequencing were performed for an adolescent male patient with CRS who was diagnosed with undifferentiated pleomorphic sarcoma (UPS) by three contemporary institutions.
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