Publications by authors named "Kennedy Tobin"

Mosquitoes use a wide range of cues to find a host to feed on, eventually leading to the transmission of pathogens. Among them, olfactory cues (e.g.

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Therapeutic neoantigen cancer vaccines have limited clinical efficacy to date. Here, we identify a heterologous prime-boost vaccination strategy using a self-assembling peptide nanoparticle TLR-7/8 agonist (SNP) vaccine prime and a chimp adenovirus (ChAdOx1) vaccine boost that elicits potent CD8 T cells and tumor regression. ChAdOx1 administered intravenously (i.

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Mosquitoes use a wide range of cues to find a host to feed on, eventually leading to the transmission of pathogens. Among them, olfactory cues ( , host emitted odors, including CO , and skin volatiles) play a central role in mediating host seeking behaviors. While mosquito olfaction can be impacted by many factors, such as the physiological state of the insect ( , age, reproductive state), the impact of environmental temperature on the olfactory system remains unknown.

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Therapeutic cancer vaccines are designed to increase tumor-specific T cell immunity. However, suppressive mechanisms within the tumor microenvironment (TME) may limit T cell function. Here, we assessed how the route of vaccination alters intratumoral myeloid cells.

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Personalized cancer vaccines are a promising approach for inducing T cell immunity to tumor neoantigens. Using a self-assembling nanoparticle vaccine that links neoantigen peptides to a Toll-like receptor 7/8 agonist (SNP-7/8a), we show how the route and dose alter the magnitude and quality of neoantigen-specific CD8 T cells. Intravenous vaccination (SNP-IV) induced a higher proportion of TCF1PD-1CD8 T cells as compared to subcutaneous immunization (SNP-SC).

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Article Synopsis
  • Personalized cancer vaccines that target unique tumor-specific neoantigens show promise, but variability in these neoantigens creates manufacturing challenges.
  • The researchers developed a new vaccine platform (SNP-7/8a) using charge-modified peptide-TLR-7/8a conjugates that can self-assemble into uniform nanoparticles, ensuring consistent loading of diverse neoantigens.
  • In experiments, SNP-7/8a successfully triggered CD8 T cell responses against nearly 50% of tested neoantigens in mice, and also stimulated T cells in nonhuman primates, indicating its potential for broad application in cancer immunotherapy.
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Mosquitoes rely on the integration of multiple sensory cues, including olfactory, visual, and thermal stimuli, to detect, identify, and locate their hosts [1-4]. Although we increasingly know more about the role of chemosensory behaviors in mediating mosquito-host interactions [1], the role of visual cues is comparatively less studied [3], and how the combination of olfactory and visual information is integrated in the mosquito brain remains unknown. In the present study, we used a tethered-flight light-emitting diode (LED) arena, which allowed for quantitative control over the stimuli, and a control theoretic model to show that CO modulates mosquito steering responses toward vertical bars.

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