Publications by authors named "Kennedy J Borle"
Article Synopsis
- High-altitude natives, like Sherpas, have developed physical strategies for survival and reproduction, but the effects of altitude and exercise during pregnancy haven't been studied much above 3,700 m.
- A case study observed a 28-year-old pregnant Sherpa woman engaging in substantial physical activity (250-300 min daily) while ascending from 3,440 m to ~5,300 m over 8 days, and again 10 months postpartum.
- No complications were noted for the mother, fetus, or newborn, highlighting the unique interplay of pregnancy, altitude, and physical activity among high-altitude populations and raising new research questions.
Intra-individual variability in the magnitude of human cerebrovascular and respiratory chemoreflex responses is largely unexplored. By comparing response magnitudes of cerebrovascular CO reactivity (CVR; middle and posterior cerebral arteries; MCA, PCA), central (CCR; CO) and peripheral respiratory chemoreflexes (PCR; CO and O), we tested the hypothesis that a within-individual reactivity magnitude profile could be characterized. The magnitudes of CVR and CCR were tested with hyperoxic rebreathing and PCR magnitudes were tested through transient respiratory tests (TT-CO, hypercapnia; TT-N, hypoxia).
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