Publications by authors named "Kennedy E Griffin"
DNA Repair (Amst)
June 2023
Article Synopsis
- Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder that causes accelerated aging and typically results in a life expectancy of around 14 years.
- The condition is primarily caused by a mutation in the LMNA gene, which leads to the production of a harmful protein called progerin, affecting DNA repair processes.
- Research indicates that progerin expression increases the occurrence of imprecise DNA end-joining during repair, moving away from the more accurate homologous recombination method, potentially contributing to the symptoms of accelerated aging in HGPS patients.
