Publications by authors named "Kennardy D Kusuma"
The disturbing increase in the number of bacterial pathogens that are resistant to multiple, or sometimes all, current antibiotics highlights the desperate need to pursue the discovery and development of novel classes of antibacterials. The wealth of knowledge available about the bacterial cell division machinery has aided target-driven approaches to identify new inhibitor compounds. The main division target being pursued is the highly conserved and essential protein FtsZ.
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- Bacterial cell division requires precise coordination between chromosome segregation and cell division to ensure DNA is evenly distributed to progeny.
- Coccoid bacteria divide in three orthogonal planes, necessitating unique spatial regulation compared to rod-shaped bacteria.
- Research revealed that the protein DnaK interacts with FtsZ and other divisome components, indicating that DivIVA plays a crucial role in coordinating these processes in coccoid bacteria.