Effects of theophylline on chronic inflammatory lung injury induced by LPS exposure in guinea pigs.

Background: Pathogenesis of COPD is, at least in part, attributable to the chronic accumulation of neutrophils in the airways, and morphological changes such as hyperplasia of goblet cells in the airways are often observed in this disease. These structural changes were induced in guinea pigs by repetitive inhalations of LPS, and the effects of theophylline and dexamethasone were examined.

Methods: Male Hartley Guinea pigs weighing about 300 g were exposed to a nebulized solution of LPS (30 microg/mL) for 1 hour.

Structure of the temporal organ of the Japanese house centipede, Thereuonema hilgendorfi Verhoeff.

The ultrastructure of the temporal organ of the Japanese house centipede, Thereuonema hilgendorfi Verhoeff (Chilopoda), has been examined. The temporal organ of this species is known to be a carbon dioxide receptor. It appears externally as a small protuberance with a small opening (5 μm) on its summit.