Publications by authors named "Kenji Omae"
Objectives: Seated voiding may be an attempt to obviate voiding dysfunction, improve physical stability during voiding, and prevent messy bathroom contamination. Therefore, we hypothesized that seated voiders had a higher prevalence of lower urinary tract symptoms (LUTS), deteriorating health conditions, and a higher marriage rate than standing voiders.
Methods: Of the participants from the 2023 Japan Community Health Survey conducted by the Japanese Continence Society, 2936 men (mean age: 53.
Article Synopsis
- The study aimed to investigate underactive bladder (UAB) characteristics in participants of the 2023 Japan Community Health Survey, involving 6,210 people aged 20-99.
- Results showed a higher prevalence of UAB in men (9.3%) compared to women (4.0%), with increased prevalence correlating with age and a greater occurrence of storage symptoms in those with UAB.
- The findings suggested that frailty and certain comorbidities were independently linked to UAB, highlighting its significant impact on health in the community.
Article Synopsis
- The study reviews statistical and machine learning methods for estimating heterogeneous treatment effects (HTEs) in randomized controlled trials (RCTs), highlighting a lack of comprehensive resources on these algorithms.
- A scoping review of literature from 2010 to 2022 found 32 studies using advanced methods, with causal forest being the most frequently applied approach.
- The review emphasizes the importance of selecting appropriate algorithms based on model performance for practical applications in clinical settings.
Article Synopsis
- - A nationwide survey in Japan in 2023 found that 77.9% of participants aged 20 and older reported lower urinary tract symptoms (LUTS), with prevalence increasing to 82.5% among those 40 and older.
- - The study included 6,210 participants (3088 females and 3122 males) and revealed that conditions like overactive bladder (OAB) affected 11.9% of the younger age group (≥20) and 13.8% of those 40 and older.
- - Despite the high prevalence and negative impact of LUTS on daily life, few participants sought medical treatment, highlighting the need for increased awareness and education on the subject.
Background: There are few comparative studies on dual immune checkpoint inhibitors (ICIs) (i.e., IO-IO) and combination therapies comprising ICIs plus tyrosine kinase inhibitors (TKIs) (i.
View Article and Find Full Text PDFBackground: Considering the reported greater benefits of immunotherapy and its unignorable adverse events in adjuvant therapy for high-risk renal cell carcinoma (hrRCC), accurate prediction may optimize drug use.
Methods: The primary objective of this study was to generate a score-based prognostic model of recurrence-free survival in hrRCC. The study retrospectively evaluated 456 patients at two institutions who underwent radical surgery for nonmetastatic pT3-4 and/or N1-2 or pT2 and G4 disease.
Aim: We compared survival and perioperative outcomes of robot-assisted laparoscopic partial nephrectomy (RAPN) and laparoscopic radical nephrectomy (LRN) for older patients (age 70 years or older) with stage 1 renal cell carcinoma (RCC).
Methods: This retrospective, single-center study included 260 patients who underwent RAPN and 44 patients who underwent LRN. The overall survival (OS) and perioperative outcomes were compared between these two groups using an inverse probability of treatment weighting (IPTW) analysis.
Objectives: To investigate predictive factors and oncological outcomes of pathological T3a upstaging in renal cell carcinoma patients who were initially diagnosed as clinical T1 and treated with partial nephrectomy.
Methods And Materials: The clinical records and survival data of 1617 patients, who had undergone partial nephrectomy for clinical T1 renal cell carcinoma at Tokyo Women's Medical University, Tokyo, Japan between January 2011 and December 2020, were analyzed retrospectively.
Results: Of 1617 clinical T1 renal cell carcinoma patients who underwent partial nephrectomy, 28 (1.
Article Synopsis
- * A study using a Japanese health insurance database revealed that people with diabetes have a higher incidence of UTIs compared to those without; however, male patients prescribed SGLT2 inhibitors were less likely to develop UTIs.
- * For female patients, the use of SGLT2 inhibitors did not significantly affect UTI rates, although younger females seemed to benefit, showing lower UTI risk with the medication.
Article Synopsis
- - The study focused on identifying risk factors for COVID-19 deterioration in unvaccinated individuals under 65 years old during Japan's fifth wave, as many cases occurred in this demographic.
- - Researchers analyzed data from 1,675 patients in Fukushima and created predictive scores to estimate deterioration risk using logistic regression, highlighting significant factors like age, body temperature, oxygen saturation, and comorbidities (diabetes, obesity).
- - The findings indicated that 8.6% of patients experienced deterioration, with predictors including older age, male gender, and various health issues; two risk scores were developed, DOATS and DOAT, to assess patient risk.
Purpose: Our objective was to investigate the impact of albumin-bilirubin (ALBI) score at the time of post-hepatectomy hepatocellular carcinoma (HCC) recurrence on survival after recurrence (SAR). We further explored the perioperative factors associated with the ALBI score at recurrence.
Methods: Patients who underwent primary hepatectomy for HCC between 2007 and 2018 and developed recurrence were included in the study.
Article Synopsis
- The study examined the link between social isolation/loneliness and tooth loss in older Japanese adults, analyzing responses from 4,645 participants aged 75 and older from the Sukagawa Study.
- Results indicated that loneliness was significantly associated with tooth loss and reduced oral care behaviors, while social isolation did not show a similar link.
- The findings suggest that addressing loneliness could be important for improving oral health among elderly populations, which may help guide policymakers and healthcare professionals.
Chronic kidney disease (CKD) is one of the most disabling disorders with significant comorbidity and mortality. Incidence and prevalence of CKD in cancer survivors are remarkably high in both adults and pediatric patients. The reasons for this high incidence/prevalence are multifold but kidney damage by cancer itself and cancer treatment (pharmacotherapy/surgery/radiation) are the main reasons.
View Article and Find Full Text PDFWe aimed to evaluate the renoprotective effects of remote ischemic preconditioning (RIPC) in patients undergoing robot-assisted laparoscopic partial nephrectomy (RAPN). Data from 59 patients with solitary renal tumors who underwent RAPN with RIPC comprising three cycles of 5-min inflation to 200 mmHg of a blood pressure cuff applied to one lower limb followed by 5-min reperfusion by cuff deflation, from 2018 to 2020 were analyzed. Patients who underwent RAPN for solitary renal tumors without RIPC between 2018 and 2020 were selected as controls.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to explore how internet usage among older adults affected their compliance with COVID-19 safety measures during Japan's first state of emergency.
- Out of nearly 9,000 participants aged 75 and older, around 40% reported using the internet, and those who did were more likely to follow preventive behaviors like hand sanitizing and getting vaccinated.
- The findings highlight a digital divide, indicating that older adults who used the internet were more adaptive to new safety recommendations, suggesting future research should focus on the types of online resources accessed by this age group.
In this study, we aimed to determine whether paid work has an impact on health-related quality of life (HRQOL) among older adults. Over three years, we longitudinally collected data from 5,260 community-dwelling older adults aged 75 years or older from a city in Japan. We assessed HRQOL using the Short-Form-8.
View Article and Find Full Text PDFChronic kidney disease(CKD)associated with cancer and its treatment affects life after cancer treatment. There is inconclusive opinion on whether CKD treatment in survivors after cancer treatment needs special care differently than in the general population with CKD. Several topics were discussed by nephrologists, urologists and medical oncologists, pediatricians, pharmaceutical specialists, and others based on the results of a literature search, and the consensus was documented in the "Clinical Practice Guidelines for the Management for Kidney Injury During Anticancer Drug Therapy, 2022".
View Article and Find Full Text PDFBackground: To what extent the COVID-19 pandemic and its containment measures influenced mental health in the general population is still unclear.
Purpose: To assess the trajectory of mental health symptoms during the first year of the pandemic and examine dose-response relations with characteristics of the pandemic and its containment.
Data Sources: Relevant articles were identified from the living evidence database of the COVID-19 Open Access Project, which indexes COVID-19-related publications from MEDLINE via PubMed, Embase via Ovid, and PsycInfo.
Importance: The US Food and Drug Administration (FDA) grants accelerated approval according to surrogate measures of numerous drug indications for serious or life-threatening illnesses such as infectious diseases and cancer. Investigators, including the FDA, have evaluated the program's regulatory and clinical consequences in oncology, but evaluation of nononcology drugs is lacking.
Objective: To evaluate the accelerated approval program for nononcology drug indications over a period of 26 years.
Objectives: Our objectives were to examine the magnitude of the proportion attributable to contextual effects (PCE), which shows what proportion of the treatment arm response can be achieved by the placebo arm across various interventions, and to examine PCE variability by outcome type and condition.
Design: We conducted a meta-epidemiological study.
Setting: We searched the Cochrane Database of Systematic Reviews with the keyword 'placebo' in titles, abstracts and keywords on 1 January 2020.
Background: Given the growing diversity among cancer survivors and the fact that oncologists typically do not perform long-term care, the expected role of primary care physicians (PCPs) in survivor care is expanding. However, communication and collaboration between oncologists and PCPs are lacking. Therefore, we assessed the perception of cancer survivor care among PCPs.
View Article and Find Full Text PDFPurpose: To investigate the feasibility of continuing aspirin therapy in patients with renal tumours undergoing robot-assisted laparoscopic partial nephrectomy.
Methods: This retrospective, single-centre study included 106 patients receiving aspirin therapy who underwent robot-assisted laparoscopic partial nephrectomy. The patients were divided into two groups, including those continuing and discontinuing aspirin therapy, and their surgical outcomes were compared.
The study's aim was to externally validate a new predictive model for the new baseline glomerular filtration rate (NB-GFR) postnephrectomy among Japanese patients. Patients with renal tumors who underwent radical nephrectomy (RN) or robot-assisted laparoscopic partial nephrectomy (PN) at a single Japanese institution during the period 2000-2020 were retrospectively analyzed. The NB-GFR is defined as the final estimated glomerular filtration rate within postoperative 3-12 months.
View Article and Find Full Text PDFObjective: This study aimed to evaluate the influence of advanced glycation end-product (AGE) accumulation on the prevalence and severity of overactive bladder (OAB) in community-dwelling elderly adults.
Methods: We conducted a cross-sectional study involving 269 Japanese community dwellers aged ≥75 years in 2015. AGE accumulation was non-invasively measured via skin autofluorescence (SAF) values using AGE Reader.