Similarity and difference between systemic lupus erythematosus and NZB/W F1 mice by multi-omics analysis.

Objectives: Several animal disease models have been used to understand the mechanisms of systemic lupus erythematosus (SLE); however, the translation of findings from animals to humans has not been sufficiently examined in drug development. To confirm the validity of New Zealand black x New Zealand white (NZB/W) F1 mice as an SLE model, we extensively characterized SLE patients and NZB/W F1 mice by omics analysis.

Methods: Peripheral blood from patients and mice and spleen and lymph node tissue from mice were analysed using cell subset analysis, cytokine panel assays, and transcriptome analysis.

Extended single-dose toxicity study of [At]NaAt in mice for the first-in-human clinical trial of targeted alpha therapy for differentiated thyroid cancer.

Objective: Astatine (At) is a promising alpha emitter as an alternative to iodine (I). We are preparing the first-in-human (FIH) clinical trial of targeted alpha therapy for differentiated thyroid cancer in consultation with Pharmaceuticals and Medical Devices Agency. Here, we performed an extended single-dose toxicity examination under a reliability standard, as a preclinical safety assessment of [At]NaAt to determine the FIH dose.

Metabolomic approach to the exploration of biomarkers associated with disease activity in rheumatoid arthritis.

We aimed to investigate metabolites associated with the 28-joint disease activity score based on erythrocyte sedimentation rate (DAS28-ESR) in patients with rheumatoid arthritis (RA) using capillary electrophoresis quadrupole time-of-flight mass spectrometry. Plasma and urine samples were collected from 32 patients with active RA (DAS28-ESR≥3.2) and 17 with inactive RA (DAS28-ESR<3.

A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model.

The Janus kinase (JAK) family of tyrosine kinases is associated with various cytokine receptors. JAK1 and JAK3 play particularly important roles in the immune response, and their inhibition is expected to provide targeted immune modulation. Several oral JAK inhibitors have recently been developed for treating autoimmune diseases, including rheumatoid arthritis (RA).

AS2553627, a novel JAK inhibitor, prevents chronic rejection in rat cardiac allografts.

Janus family kinases (JAKs) are essential molecules for cytokine responses and attractive targets for the treatment of transplant rejection and autoimmune diseases. Several JAK inhibitors have shown demonstrable effects on acute rejection in experimental cardiac transplant models. However, little is known about the potential benefits of JAK inhibitors on chronic rejection outcomes such as vasculopathy and fibrosis.

Occlusal pressure pattern analysis of complete dentures for evaluation of occlusal adjustment.

The purpose of this study was to investigate occlusal pressure patterns of complete denture wearers to evaluate progress of occlusal adjustment of dentures. Thirty three edentulous subjects volunteered to participate in this study. A computer-based device was used to measure occlusal pressure sequence while tapping with their new dentures.

[A clinical application of the T-Scan II system--usefulness for evaluating occlusal contacts of complete denture wearers].

The purpose of this study was to assess the reproducibility of the T-Scan II system and its clinical usefulness for evaluating occlusal contacts of complete denture wearers. The occlusal contacts of 13 dentate subjects, and 14 complete denture wearers, were recorded using a T-Scan II system during maximum voluntary clenching. The recordings for complete denture wearers were taken after each treatment for the new denture, and continued until the completion of all corrections.

[In vitro study on accuracy and repeatability of the T-Scan II system].

The T-Scan system has been used to analyze the distribution of occlusal loading forces, and occlusal contact variability. An enhanced version, the T-Scan II system, has been developed with clinical significance of its center of force. The T-Scan II system was also found to be clinically useful for measuring simultaneous occlusal contacts bilaterally.