Publications by authors named "Kenji Ohsuga"
Purpose: Intravenous sedation (IVS) with propofol (PPF) is commonly performed in dental treatment, particular in patients with dentophobia, with gag reflex, or undergoing implant surgeries, as PPF has the advantages of rapid induction and recovery. However, PPF and other intravenous sedatives may cause respiratory depression. Thus, IVS with PPF requires oxygen administration.
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- Recent animal studies indicate that GABA type A (GABA-) receptors may inhibit salivation, prompting this study to assess propofol's effects on saliva production.
- Twenty healthy male volunteers were given propofol, and saliva flow rates from various glands were measured before, during, and after the drug infusion.
- Results showed a significant decrease in salivary flow rates and amylase activity during propofol sedation, suggesting its potential use in dental treatments requiring reduced saliva.