Synopsis of recent research by authors named "Kenji Kasuno"
- Kenji Kasuno's research primarily focuses on the mechanisms of kidney injury and protective strategies against nephrotoxicity, particularly in the context of chemotherapeutic agents like cisplatin and doxorubicin, as well as metabolic interventions using compounds like dichloroacetate and fenofibric acid.
- His findings highlight the roles of various signaling pathways and nuclear receptors, such as PPAR-α and PPAR-δ, in mitigating renal damage, suggesting that specific targeting of these pathways could improve outcomes in conditions such as doxorubicin-induced nephropathy and cisplatin toxicity.
- Kasuno has also explored novel therapeutic approaches, such as low-density lipoprotein (LDL) apheresis and extracellular fibroblast-specific protein 1 (FSP1) as potential biomarkers, indicating their utility in diagnostics and treatment of chronic kidney diseases, emphasizing the importance of a personalized medicine approach in renal pathologies.
