Publications by authors named "Kenji Inada"
Article Synopsis
- The study investigates how the complement component C5a influences the activation of immune cells and the secretion of the proinflammatory cytokine IL-1β in response to inflammation.
- Human peripheral blood mononuclear cells (PBMCs) were stimulated with C5a, showing that this component enhances IL-1β production and caspase-1 activation, particularly in monocytes.
- The findings suggest that C5a independently drives the production of mature IL-1β mainly through the activation of caspase-1 in CD14 monocytes, highlighting its role in inflammatory processes.
