Publications by authors named "Kenji Hinotsu"
Article Synopsis
- * The study examined the presence of anti-NR1/NR2B IgG antibodies in patients initially diagnosed with schizophrenia, mood disorders, or epilepsy, finding that a significant percentage met the atypical psychosis criteria, with some showing antibodies linked to anti-NMDAR encephalitis.
- * Early immunotherapy led to good outcomes for most patients with antibodies, highlighting the importance of lumbar puncture and antibody testing in those with atypical psychosis and abnormal EEG results.
Impairment of early neuronal maturation in anti-NMDA-receptor encephalitis.
Psychopharmacology (Berl)
February 2022
Rationale: Adequate immunotherapies for anti-NMDAR encephalitis during pregnancy produce a relatively good clinical outcome for pregnant mothers and their infants, but there are no reports about the future growth of their babies. The damage of anti-NMDAR antibodies to early neuronal development is still unknown.
Objectives: Serum or cerebrospinal fluid from one patient with anti-NMDAR encephalitis (the index patient) and one patient with schizophrenia (the control patient) was administered to primary cultures of dissociated rat cortical neurons, and dendritic outgrowth, centrosome elimination, and branching of dendrites were investigated.
Background: Recently, depression with Lewy body pathology before the appearance of parkinsonism and cognitive dysfunction has been drawing attention. Low cardiac metaiodobenzylguanidine (MIBG) uptake is helpful for early differentiation of Lewy body disease (LBD) from late-onset psychiatric disorders even before parkinsonism or dementia appears. In this study, we used MIBG uptake as a tool in suspected LBD, and evaluated the relationship of MIBG results to clinical characteristics and depressive symptoms.
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