Multiple Abnormal Cutaneous Findings in a Patient With Hypomelanosis of Ito Undergoing General Anesthesia.

Hypomelanosis of Ito (HI), a neurocutaneous syndrome, is characterized by skin depigmentation and skeletal, muscular, central nervous system, cardiac, and renal manifestations. A wide variety of cutaneous manifestations besides depigmentation have been reported. Herein we describe a 23-year-old woman with HI whose extracutaneous symptoms included severe mental and motor impairment, convulsions, and deformity of the orofacial region.

Enhancement of receptor-mediated calcium responses by phenytoin through the suppression of calcium excretion in human gingival fibroblasts.

Background And Objectives: Gingival overgrowth caused by phenytoin is proposed to be associated with Ca signaling; however, the mechanisms that increase the intracellular Ca concentration ([Ca ] ) are controversial. The current study aimed to elucidate the mechanism underlying the phenytoin-induced increase in [Ca ] in human gingival fibroblasts (HGFs).

Methods: Effects of 100 μM phenytoin on [Ca ] in HGFs were examined at the single-cell level using fluorescence images of fura-2 captured by an imaging system consisting of an EM-CCD camera coupled to an inverted fluorescence microscope at room temperature.