Optic neuropathy secondary to granulomatosis with polyangiitis in a patient with Graves' disease: a case report.

Background: Dysthyroid optic neuropathy is the most commonly suspected diagnosis of optic neuropathy in Graves' patients; however, other causes need to be ruled out. We present a unique case of optic neuropathy secondary to hypertrophic pachymeningitis with antineutrophil cytoplasmic antibody-associated vasculitis, which was suspected to be antithyroid drug related.

Case Presentation: A 79-year-old Japanese male presented with acute visual loss in the left eye.

Up-regulation of CX3CR1 on tonsillar CD8-positive cells in patients with IgA nephropathy.

Although tonsillectomy are used as therapeutic options to prevent chronic renal failure in IgA nephropathy (IgAN) patients, the relationship between IgAN and tonsils is not fully proved by basic research. Recently, circulating CX3CR1-positive cells were reportedly involved in promoting hematuria in patients with IgAN. In this study, we focused on the expression of CX3CR1 in tonsillar mononuclear cells in IgAN patients.

Stimulation of denervated muscle promotes selective reinnervation, prevents synkinesis, and restores function.

Objectives/hypothesis: Previously, electrical stimulation of denervated canine laryngeal muscle was shown to promote reinnervation by native over foreign motoneurons. The goal of this study was to assess the effect of different stimulus paradigms on reinnervation quality and functional recovery.

Study Design: A prospective study of six canines over 8 to 20 months.

Intra-arterial cisplatin with concomitant radiation for advanced hypopharyngeal cancer.

Objectives/hypothesis: The current study evaluated the efficacy of radiation and concomitant high-dose superselective intra-arterial cisplatin infusion (RADPLAT) for patients with advanced hypopharyngeal cancer.

Study Design: Retrospective, single-institutional study.

Methods: Between February 2004 and October 2010, 43 patients with T2N0 or worse cancer were given superselective intra-arterial infusions of cisplatin (100-mg/m(2) or 75-mg flat dose per week) with simultaneous intravenous infusions of thiosulfate to neutralize cisplatin toxicity and conventional external beam radiotherapy (60-66 Gy).

Bilateral motion restored to the paralyzed canine larynx with implantable stimulator.

Objectives/hypothesis: Bilateral stimulation of posterior cricoarytenoid (PCA) muscles offers a physiologic approach to restore ventilation to a normal level in case of bilateral laryngeal paralysis. The objective of this study was to evaluate the long-term efficacy and safety of a new generation stimulator in restoring ventilation and exercise tolerance.

Study Design: A prospective study of four canines over 8-20 months.

Rehabilitation of bilaterally paralyzed canine larynx with implantable stimulator.

Objectives/hypothesis: Bilateral stimulation of the posterior cricoarytenoid (PCA) muscles offers a physiologic approach to rehabilitate ventilation to a normal level in case of bilateral laryngeal paralysis. The objective was to evaluate the safety and efficacy of a new generation stimulator in restoring glottal opening, ventilation, and exercise tolerance.

Study Design: A prospective study in three canines over 6 to 17 months.