Mechanisms of the action of adenine on anti-allergic effects in mast cells.

Introduction: Mast cells play an important role in allergic responses.

Methods: We herein demonstrated the mechanisms of inhibitory effect of adenine on IgE/antigen-induced degranulation and TNF-α release in mast cells.

Results: We found that these effects were dependent on the amino group of adenine because purine only weakly inhibited degranulation.