Dehydrogenative Annulation of Silylated 1-Indoles with Alkynes via Silyl Migration.

We investigated the dehydrogenative annulation of silylated 1-indole derivatives with alkynes to synthesize a silole-fused indole. The addition of the generated silylium ion to alkynes was followed by the sila-Friedel-Crafts reaction via silyl migration, realizing regioselective dehydrogenative annulation controlled by the steric bulkiness of a base. The optical properties of the obtained siloloindoles indicated fluorescence of which the intensity depends on the location of the fused silole.

The Steric Effect in Preparations of Vanadium(II)/(III) Dinitrogen Complexes of Triamidoamine Ligands Bearing Bulky Substituents.

The reactions of newly designed lithiated triamidoamines Li ( = iPr, Pen, and Cy) with VCl(THF) under N yielded dinitrogen-divanadium complexes with a μ-N between vanadium atoms [{V()}(μ-N)] ( = iPr () and Pen ()) for the former two, while not dinitrogen-divanadium complexes but a mononuclear vanadium complex with a vacant site, [V()] ( = Cy ()), were obtained for the third ligand. The V-N and N-N distances were 1.7655(18) and 1.

Synthesis of 1-Silabenzo[,]isochromanes via Electrophilic Aromatic Substitution of Aldehydes Activated by Silylium Ion.

A strong Lewis acid silylium ion was utilized for dehydrogenative annulation between dialkyl(1-naphthyl)silanes and aldehydes . Silane was reacted with [PhC][B(CF)] in the presence of 2,6-di--butyl-4-methylpyridine and aldehydes to afford the annulation product, 1-silabenzo[,]isochromanes in moderate isolated yields. The annulation occurred only at the 8-position on the 1-naphthyl group.

Effect of Counteranions in Electrocatalytic Hydrogen Generation Promoted by Bis(phosphinopyridyl) Ni(II) Complexes.

We previously reported the preparation and characterization of a Ni(II) complex capable of electrocatalytic hydrogen generation. The complex [Ni()Cl]Cl () includes a 6-((diphenylphosphino)methyl)pyridin-2-amine ligand (), which has an amino group as a base that acts as a proton transfer site by virtue of its location near the metal center. In order to study the effect of counteranions in hydrogen generation, two additional Ni() complexes with weakly coordinating/noncoordinating counteranions, [Ni()](OTs) (OTs = -toluenesulfonate) () and [Ni()](BF) (), were synthesized.

Dual-Energy Computed Tomography in Patients With Small Hepatocellular Carcinoma: Utility of Noise-Reduced Monoenergetic Images for the Evaluation of Washout and Image Quality in the Equilibrium Phase.

Purpose: This study aimed to evaluate the utility of virtual monoenergetic images for detecting washout of small (≤2 cm) hepatocellular carcinoma (HCC) in the equilibrium phase.

Methods: We performed 120-kVp-equivalent linear-blended (M120) and monoenergetic reconstructions from 40 to 90 keV by standard (40, 50, 60, 70, 80, 90) and novel noise-reduced (nMERA: 40+, 50+, 60+, 70+, 80+, 90+) monoenergetic reconstruction algorithms. Image quality and tumor visibility of delayed washout of HCCs in the equilibrium phase were compared between standard monoenergetic reconstruction algorithm and nMERA by objective and subjective analyses.

Black-hole universe: time evolution.

Time evolution of a black hole lattice toy model universe is simulated. The vacuum Einstein equations in a cubic box with a black hole at the origin are numerically solved with periodic boundary conditions on all pairs of faces opposite to each other. Defining effective scale factors by using the area of a surface and the length of an edge of the cubic box, we compare them with that in the Einstein-de Sitter universe.

First isolation of Desulfovibrio from the human vaginal flora.

Four Desulfovibrio species, including 2 subtypes of 1 species, namely, Desulfovibrio piger, Desulfovibrio desulfuricans MB subtype and Essex 6 subtype, Desulfovibrio fairfieldensis, and Desulfovibrio vulgaris, have been isolated from the human oral and intestinal flora, but not previously from the vaginal flora. They are opportunistic pathogens and have been considered as possible environmental and etiologic agents involved in ulcerative colitis and chronic periodontitis. We isolated Desulfovibrio intestinalis from vaginal specimens of four Japanese women; a species which has not been previously isolated from humans.

Susceptibilities of 23 Desulfovibrio isolates from humans.

Antimicrobial susceptibilities of 23 strains of Desulfovibrio spp. were tested by Etest. Generally, Desulfovibrio spp.

In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria.

The antianaerobic activity of tomopenem, a new longer-half-life parenteral carbapenem, was compared with other carbapenems. Tomopenem showed broad activity against 63 reference species. The activity of tomopenem against 293 clinical isolates was potent (MIC(90), 0.

[Application of "Microring AN" to "Level 1": presumptive identification of anaerobic gram-negative bacilli].

Commonly isolated anaerobic gram-negative rods (4 genus 64 strains), some other important gram-negative anaerobic species (9 genus 45 strains), and cigar-shaped clostridia (11 strains) were studied on their susceptibility patterns to 6 agents on "Microring AN". Some modifications were made in the methods and interpretation of results. Susceptibility patterns to erythromycin, rifampicin, colistin, benzylpenicillin, kanamycin, and vancomycin were following (sensitive [S], intermediate [I], resistant [R], variable [V]): for Bacteroides fragilis group, V, S, R, R, R, R, respectively; for non-pigmented Prevotella, V, S, V, V, R, R, respectively; for pigmented Prevotella, S, S, SR, V, V, R, respectively: for Fusobacterium nucleatum/necrophorum, R(S), S(I), S(IR), S(R), S, R, respectively; and for F.

In vitro antianaerobic activity of DX-619, a new des-fluoro(6) quinolone.

The in vitro activity of DX-619, a new des-F(6) quinolone, against anaerobic bacteria was evaluated. DX-619 showed potent activity against Bacteroides, Prevotella, Fusobacterium, Micromonas, Actinomyces, and Clostridium spp., with MIC(50)s/MIC(90)s of View Article and Find Full Text PDF