Novel biallelic loss-of-function KCNV2 variants in cone dystrophy with supernormal rod responses.

Purpose: To report clinical and genetic features including long-term full-field electroretinography (FF-ERG) findings of a patient with cone dystrophy with supernormal rod responses (CDSRR).

Methods: Ophthalmological medical records including FF-ERG were retrospectively reviewed. Genetic analysis using whole-exome sequencing (WES) was performed.

Combination Surgery With Transcorneal Microincision Vitrectomy Surgery and Intrascleral Intraocular Lens Fixation for Spontaneous Intraocular Lens Luxation.

To present a combination technique for two cases of in-the-bag intraocular lens (IOL) luxation into the vitreous cavity. Vitrectomy was performed via a cornea microincision vitrectomy system, and the luxated IOL was fixed into the sclera. IOL fixation is simple from no trocar cannulas and less disrupted conjunctiva.

Efficacy of Intravitreal Triamcinolone Acetonide for Diabetic Macular Edema After Vitrectomy.

Purpose: To compare the efficacy of intravitreal injection of triamcinolone acetonide (IVTA) for diabetic macular edema (DME) in vitrectomized eyes with DME without vitrectomy eyes.

Methods: This retrospective comparative study evaluated the efficacy of IVTA treatment of DME in 26 consecutive eyes (23 patients). Changes in mean best-corrected visual acuity (VA) and mean central retinal thickness (CRT) were retrospectively evaluated before IVTA and during the 6-month period after IVTA.

Improved Photoreceptor Function in Male Acute Zonal Occult Outer Retinopathy.

Purpose: To describe male acute zonal occult outer retinopathy (AZOOR) patients with improvement of photoreceptor structure and visual function.

Case Series: Medical records for eight eyes in seven patients (mean age, 36.9 years; range, 22 to 57 years) with AZOOR were reviewed retrospectively.

Resolution of acute photoreceptor damage as revealed by serial SD-OCT.

Purpose: To describe findings in spectral-domain optical coherence tomography (SD-OCT) for four patients with acute foveal photoreceptor damage.

Case Report: Four patients with acute foveal photoreceptor damage were evaluated by color photography and SD-OCT during follow-up. All four cases were Japanese patients with high myopia.

Electroretinography in streptozotocin diabetic rats following acute intraocular pressure elevation.

Background: We consider whether pre-existing streptozotocin induced hyperglycemia in rats affects the ability of the eye to cope with a single episode of acute intraocular pressure (IOP) elevation.

Methods: Electroretinogram (ERG) responses were measured (-6.08 to 1.

Use of DNA microarray analysis in diagnosis of bacterial and fungal endophthalmitis.

Background: To examine the utility of DNA microarray analysis for identifying causative microorganisms in endophthalmitis.

Methods: Thirteen samples of vitreous fluid (VF) were obtained from 13 patients during vitrectomy. Vitreous fluids from three patients with suspected endophthalmitis and ten controls without infection were subjected to testing for the presence of bacteria and fungi in culture tests, polymerase chain reaction (PCR) analysis, and DNA microarray analysis.

[Stickler syndrome with rhegmatogenous retinal detachment].

Background: Stickler syndrome is an autosomal dominant disease characterized by various disorders of the eyes and the connective tissues throughout the body. It can arise from a mutation in the collagen associated gene. We present a case of Stickler syndrome with rhegmatogenous retinal detachment.

Mutagenicity and PAH contents of soil in forests or planted areas in Japan.

We investigated the behavior of mutagenic substances in the soil of forests or planted areas. Mutagenicity and concentration was examined for 16 types of PAHs in soil samples collected at a depth of 1 m in 10 forests in Iwate, Ibaraki, Tokyo, Kanagawa, Yamanashi and Shizuoka prefectures in Japan. Mutagenicity and PAHs were detected mostly in soil from the surface to a depth of 30 cm when strains TA100, TA98 and YG1024 were used.

Early inner retinal dysfunction in streptozotocin-induced diabetic rats.

Purpose: Diabetes is known to alter retinal function, as measured with the electroretinogram (ERG), which shows a propensity toward inner retinal oscillatory potential (OPs) abnormalities. However, the effect that diabetes has on other ganglion cell-related responses is not known. This study was a systematic evaluation of streptozotocin (STZ) diabetes-related ERG changes in rats for the first 11 weeks after diabetogenesis.

Evaluation of S-cone sensitivity in reattached macula following macula-off retinal detachment surgery.

Purpose: To investigate the recovery of short-wavelength sensitivity in patients who had undergone successful reattachment of a rhegmatogenous retinal detachment with macular involvement.

Methods: Postoperative assessment of the visual acuity and the visual fields by standard achromatic automated perimetry (SAP), and short-wavelength automated perimetry (SWAP, Humphrey visual field analyzer; macula test pattern) was performed on 12 patients after the macula was reattached. The follow-up period was up to 12 months.

[Bilateral retinal detachment after laser in situ keratomileusis].

Background: We report a case of bilateral retinal detachment after laser in situ keratomileusis(LASIK).

Case: A 49-year-old man received multiple laser photocoagulation for retinal lattice degeneration in both eyes and retinal tears in the left eye. He underwent bilateral LASIK in another country about 6 months after the laser photocoagulation.

Measurement of polynuclear aromatic hydrocarbons in canine lung after alkaline decomposition.

An alkaline decomposition method employing a KOH/alcohol solution was studied, and polynuclear aromatic hydrocarbons (PAHs) contained in particles remaining in canine lung were measured. As a result, BaA, BkF, BaP, and BghiP were found. By this method, PAHs extracted from the lungs of 32 dogs were 13.