MicroRNA Levels in Cervical Cancer Samples and Relationship with Lesion Grade and HPV Infection.

Background: miR-21, miR-214 and miR-let-7a are three validated and well-known miRNAs. miR-21 is described as an "oncomir" while miR-214 and miR-let-7a are described mainly as tumor suppressors. The role of these miRNAs remains unclear in cervical cancer, an important malignancy among women worldwide and responsible for many deaths every year.

Recurrence/Regrowth in Grade I Meningioma: How to Predict?

The HLA-G and HLA-E molecules, Ki67, progesterone (PR), estrogen (ER) and androgen receptors (AR), p53, COX-2, and HER2 were studied to assess whether the biological behavior of grade I meningiomas is related to their expression. Tissue samples from 96 patients with grade I intracranial meningiomas were analyzed by immunohistochemistry on tissue microarray blocks (TMA) using antibodies specific for HLA-G, HLA-E, Ki67, PR, ER, AR, p53, COX-2, and HER2. Meningiomas were classified as small (≤2 cm, 1.

HLA-G 14 bp and +3142 genotypes are differentially expressed between patients with grade IV gliomas and controls.

Human Leukocyte Antigen-G (HLA-G) is a non-classical class I molecule that is involved in maternal-fetal immunotolerance. In cancer, this molecule contributes to the tumor escape. The aim of this study was to evaluate the 14 bp and +3142  polymorphisms of the 3' UTR and its relation with plasma and tissue HLA-G expression in patients with grade IV (high-grade) and grade I/II (low-grade) gliomas and controls.

Profile of patients with brain tumors and the role of nursing care.

Objective: to describe the profile of 200 patients with central nervous system tumors (CNST), and the role of the nursing care.

Method: prospective, quantitative and descriptive analysis of medical records of 200 patients with TSNC.

Results: a total of 61% of our patients had benign CNST and 39% had malignant tumors.