Publications by authors named "Kengo Obata"
Article Synopsis
- The study aimed to address the challenges of assessing post-intensive care syndrome (PICS) in ICU survivors by identifying effective assessment instruments through a scoping review and consensus process.
- A total of 6972 records were reviewed, leading to 20 recommended instruments spanning various domains, including physical health, cognition, and mental health.
- The findings provide a structured approach to evaluating PICS, highlighting tools like the 6-min walk test and MoCA, ensuring comprehensive assessment for ICU survivors and their families.
Providing standardized, high-quality rehabilitation for critically ill patients is a crucial issue. In 2017, the Japanese Society of Intensive Care Medicine (JSICM) promulgated the "Evidence-Based Expert Consensus for Early Rehabilitation in the Intensive Care Unit" to advocate for the early initiation of rehabilitations in Japanese intensive care settings. Building upon this seminal work, JSICM has recently conducted a rigorous systematic review utilizing the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology.
View Article and Find Full Text PDFBackground: Epithelial ovarian cancer (EOC) is a lethal malignant tumor, for which new treatment options are urgently required. Lipolysis-stimulated lipoprotein receptor (LSR) is widely expressed in EOC, and it is associated with poor prognosis. In this study, we developed an antibody-drug conjugate (ADC) targeting LSR as a new therapeutic approach to EOC.
View Article and Find Full Text PDFBackground: Constitutive activation of STAT3 promotes oncogenesis and growth of oral squamous cell carcinoma (OSCC). We investigated the mechanism of action of suppressor of cytokine signaling 1 (SOCS1), an endogenous inhibitor of JAK, as gene therapy for OSCC.
Methods: Antitumor effect of SOCS1 was compared to JAK inhibitor I by cell proliferation assay, cell cycle analysis, and apoptosis analysis in vitro.
Article Synopsis
- The study aimed to establish minimum clinical practice standards for physical therapists in Japan's intensive care units (ICUs) and compare these with international standards.
- A modified Delphi method involved 54 experienced therapists rating 272 items for their essentiality, leading to 199 items being deemed essential for practice.
- The resulting standards differed from those in the UK and Australia, highlighting variations due to national laws, cultural, and historical contexts.
Early mobilization is advocated to prevent intensive care unit-acquired physical weakness, but the patient's workload and its changes in response to body position changes have not been established. We used indirect calorimetry to determine the energy expenditure (EE) in response to body position changes, and we assessed EE's correlation with respiratory parameters in healthy volunteers: 8 males and 8 females, mean age 23.4±1.
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