Publications by authors named "Keng-Hsuan Lin"
Fibrinogen-fibrin degradation products (DR-70) are derived from tumor cells or metastases. Our previous study reported the diagnostic values in dogs with tumors, but no research has yet to be conducted to establish DR-70 as a prognostic marker. Herein, we investigated changes in DR-70 concentrations and disease courses in dogs with tumors.
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- Tumor biomarkers are widely used in human medicine, but their effectiveness in veterinary medicine, particularly for dogs, is not well understood, with DR-70 being a potential candidate.
- A study involving 263 dogs with tumors and 60 healthy dogs found that DR-70 concentrations were significantly higher in dogs with tumors, indicating its diagnostic potential.
- The sensitivity and specificity of DR-70 as a tumor biomarker were found to be 84.03% and 78.33%, respectively, but further research with a broader range of canine diseases is needed to confirm its clinical usefulness.
Spinocerebellar ataxias (SCAs) are a large and diverse group of autosomal-dominant neurodegenerative diseases. No drugs have been approved for these relentlessly progressive and fatal SCAs. Our previous studies indicate that oxidative stress, neuroinflammation, and neuronal apoptosis are elevated in the SCA17 mice, which are the main therapeutic targets of hyperbaric oxygen treatment (HBOT).
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