Publications by authors named "Kenenni A Wiegand"
Article Synopsis
- Loss of RNA balance in neurons is linked to various neurodegenerative and inflammatory diseases, yet the details of how neuroinflammation starts are not well understood.
- Research shows that human neurons possess high levels of immunostimulatory double-stranded RNAs (dsRNAs) which are generated from long 3'UTRs, and specific genes can enhance both the length of these UTRs and the dsRNA levels.
- While normal neurons use dsRNAs to activate antiviral defenses, those lacking the dsRNA-editing enzyme ADAR1 face toxic inflammation and cell death, highlighting the need for RNA homeostasis to avoid harmful neuroinflammation.
