Association between +45T>G adiponectin polymorphism gene and type 2 diabetes mellitus and metabolic syndrome in a Venezuelan population.

Adiponectin (ADIPOQ) is a hormone primarily synthesized by adipocytes and encoded by the gene, which exerts anti-inflammatory, antiatheratogenic and insulin sensitizing functions. It has been shown that its plasma concentrations are decreased in individuals with metabolic syndrome (MS) and type 2 diabetes mellitus (DM2), which could be due to variations in the gene coding for this protein. The aim of this study was to detect the +45 T>G polymorphism of the gene in subjects with DM2 and MS in Maracaibo municipality, Zulia state, Venezuela.