Accuracy of admission and clinical diagnosis of tumours as revealed by 2000 autopsies.

Admission, clinical and autopsy diagnoses of tumour were computed in 2000 consecutive cases, aged 30-80 years, using data collected in two university pathology departments in Budapest, Hungary. Based on diagnosis of tumour, regardless of site, as the underlying cause of death false-negative rates were 37.4% at admission and 8.

Misdiagnosis of lung cancer in a 2000 consecutive autopsy study in Budapest.

Objective: To determine the accuracy of lung cancer mortality data based on clinical observations in the absence of autopsy and to identify factors affecting the accuracy of diagnosis.

Methods: Admission, pre-autopsy and post-autopsy diagnoses were recorded for 1000 consecutive autopsies in each of two University departments in Budapest with high autopsy rates for persons dying in hospital. In those 87 cases where one or more diagnosis included primary lung cancer, additional data were collected concerning clinical investigations relevant to the diagnosis and the histological type lung cancer, and on smoking habits.

[Diagnostic problems of Wilson disease].

A family (three siblings) of Wilson's-disease is described. The authors review the pathogenesis, diagnostics, pathology and treatment of Wilson's-disease. The diagnostic difficulties are emphasised.

Accuracy of admission and pre-autopsy clinical diagnoses in the light of autopsy findings: a study conducted in Budapest.

Pre- and post-autopsy diagnoses of underlying cause of death were compared in consecutive autopsies on persons aged 30 to 80 years; 1000 from each of two pathology departments in Budapest. Data on admission diagnoses and on contributory causes of death were also analysed. At autopsy, the percentages of deaths by underlying cause were neoplasms (any site) 34.

[Unity of diagnostic pathology, continuing education and research at our institute].

Authors give a brief view on the activity in Institute of Pathology and Histopathology of Post-graduate University of Medicine. In its frame, close relation of diagnostic, post-graduate education and research activity is illustrated by examples of different fields (intestinal, cardiac, vascular system, respiratory tract, organ of locomotion, urological diseases, electronmicroscopic tumor diagnostics, endocrinology). Importance of modern morphological methods and their place both in practical and scientific activity are dealt with.

[Pyridimocarbamate (prodectin)-induced acute liver damage, cirrhosis and primary liver cancer--accidental finding?].

Authors have verified during the postmortem of a 60-year-old woman, in addition to clinically manifested vascularly and parenchymally decompensated cirrhosis a small hepatocellular carcinoma with signs of vascularization. The patient received since four years pyridinolcarbamate (Prodectin) because of obliterating peripheral arteriosclerosis. During treatment, icterus occurred the drug-induced nature of which was proved by the provocation-test.

[Morphologic observations in liver damage in patients taking Depressan (dihydralazinum sulfuricum)].

Authors studied a 56 year old male and a 47 year old female patient having taken an antihypertonic drug for two and a half month and one year respectively observed acute HBsAg-negative liver disease. In the needle biopsy specimen obtained on the 8th day (at the male patient) and on the 10th day (at the female) of the onset of jaundice severe centrilobular liver cell necrosis was found, which in the first case was accompanied by "bridging" necrosis. In the necrosis-free areas hydropic and fatty degeneration of different degree and also cholestasis occurred.

[Diagnostic problems of primary amyloidosis].

Surgical liver biopsy specimen of a women aged 58 with "biliary complaints" showed amyloid deposits of unknown nature. After a nearly two-years-course of the disease the patient died of cardiac and renal failure. Clinical findings and laboratory tests without abnormal serum globulins suggested primary amyloidosis.

[Hepatitis B virus components and cytoplasmic virus-like corpuscles in chronic hepatitis (electron microscopic study)].

Author in the needle-biopsy specimen of the liver of a HBsAg positive patient previously treated with immunosupressive preparates (Corticosteroid + Imuran) in the nuclei of hepatocytes by the aid of electron microscope revealed ring-shaped particula of 20-25 nm in diameter (core), in the cytoplasma of ground-glass hepatocytes in the canals of the rough-surfaced endoplasmic reticulum filamentous formations in average of 23nm in diameter (surface antigen). In addition in a few number cytoplasmic core particula have also been revealed. Dane-particula were not seen.

[Core and coat of the hepatitis b-virus and cytoplasmic viruslike particles in chronic hepatitis. An electron microscopic study (author's transl)].

In the second liver biopsy material of a seropositive patient receiving immunosuppressive therapy (Corticosteroid + Imuran) for chronic active hepatitis (CAH), intranuclear, ring-shaped, 20--25 nm in diameter non-coated particles (core) of liver cells and intracisternal filaments, 23 nm in diameter (coat) of the soft ER in the "ground-glass" hepatocytes were demonstrated by electron microscopy. Core-particles in the cytoplasm were seen occasionally. Dane-particles could not be visualized.

Hepatitis B virus, cirrhosis and primary carcinoma of the liver. An electron microscopic study.

The core and coat of hepatitis B virus were found by electron microscopy in parenchymal cells of a liver biopsy from a 61 year old man with chronic active hepatitis and cirrhosis of the liver. Laparoscopy, 35 days after liver biopsy, and autopsy 42 days later confirmed the cirrhosis and showed in addition a well differentiated hepatoma. The possibility of a viral aetiology for the cirrhosis and primary carcinoma of the liver is considered.