Publications by authors named "Kendra Perez-Smith"
Article Synopsis
- Li-Fraumeni syndrome (LFS) is a genetic disorder tied to high cancer risk due to TP53 gene mutations, with no approved preventive treatments currently available, although metformin shows promise in early studies.
- The MILI trial aims to assess the effectiveness of metformin combined with annual MRI surveillance in 224 adults with LFS, measuring cancer-free and tumor-free survival over five years.
- The study will also explore metformin's safety, quality of life effects, and its potential mechanisms as a cancer preventative, while evaluating the effectiveness of MRI scans in detecting cancer in LFS patients.
