Synopsis of recent research by authors named "Kendra K Mckee"
- Kendra K McKee's research focuses on the molecular mechanisms underlying neuromuscular disorders, particularly myotonic dystrophy and amyotrophic lateral sclerosis, exploring targeted therapies involving small molecules and RNA degradation strategies to address disease pathology.
- Her studies have demonstrated that MBNL1 and MBNL2 protein depletion is critical in the cardiac manifestations associated with myotonic dystrophy, highlighting the need for comprehensive approaches to tackle cardiac-related complications in these disorders.
- McKee's work also includes significant advancements in developing small molecules, such as Cugamycin, to specifically cleave toxic RNA repeat expansions in myotonic dystrophy models, showcasing promising strategies for targeting repeat-associated diseases and potentially influencing therapeutic development.
