Serum levels of folate and cobalamin are lower in depressed than in nondepressed hemodialysis subjects.

Objective: The purpose of this study was to evaluate if there was a significant difference in serum and RBC folate or serum cobalamin levels in depressed and nondepressed subjects on hemodialysis (HD).

Design: A cross-sectional design was used in this study. Each subject's serum folate and cobalamin, and red blood cell (RBC) folate were measured.