Targeting TRPC channels for control of arthritis-induced bone erosion.

Arthritis leads to bone erosion due to an imbalance between osteoclast and osteoblast function. Our prior investigations revealed that the Ca-selective ion channel, Orai1, is critical for osteoclast maturation. Here, we show that the small-molecule ELP-004 preferentially inhibits transient receptor potential canonical (TRPC) channels.

Considering Performance in the Automated and Manual Coding of Sociolinguistic Variables: Lessons From Variable (ING).

Impressionistic coding of sociolinguistic variables like English (ING), the alternation between pronunciations like and , has been a central part of the analytic workflow in studies of language variation and change for over a half-century. Techniques for automating the measurement and coding for a wide range of sociolinguistic data have been on the rise over recent decades but procedures for coding some features, especially those without clearly defined acoustic correlates like (ING), have lagged behind others, such as vowels and sibilants. This paper explores computational methods for automatically coding variable (ING) in speech recordings, examining the use of automatic speech recognition procedures related to forced alignment (using the Montreal Forced Aligner) as well as supervised machine learning algorithms (linear and radial support vector machines, and random forests).

Perceiving Southernness: Vowel categories and acoustic cues in Southernness ratings.

Southern U.S. speech has been the focus of much sociophonetic work.

Durational and spectral differences in American English vowels: dialect variation within and across regions.

Spectral differences among varieties of American English have been widely studied, typically recognizing three major regionally diagnostic vowel shift patterns [Labov, Ash, and Boberg (2006). The Atlas of North American English: Phonetics, Phonology and Sound Change (De Gruyter, Berlin)]. Durational variability across dialects, on the other hand, has received relatively little attention.