Publications by authors named "Kendall S Bromley"
Magn Reson Chem
January 2025
Article Synopsis
- The study examines the quantitative conformations of three sugar compounds, focusing on their structural properties and behaviors in different scenarios.!
-
- It introduces new equations for predicting the relationship between certain angles (torsions) in the molecular structure of mannobiose, using experimental NMR data and advanced computational methods like molecular dynamics and DFT energy minimizations.!
-
- The findings highlight that spectral simulations can effectively refine preliminary data from theoretical calculations and suggest that studying just one key torsion can provide valuable insights into the conformational analysis of the disaccharide molecule.!
Article Synopsis
- * Mutations preventing K164 ubiquitination disrupt normal DNA replication and lead to increased replication stress, especially when paired with the DNA polymerase inhibitor aphidicolin.
- * The study highlights that impaired FANCD2 activity in response to K164 mutations reduces its ability to associate with chromatin, thereby hindering the mitotic DNA synthesis process, which is essential to prevent under-replicated DNA.
