Publications by authors named "Kenan Zheng"
Article Synopsis
- A high-performance liquid chromatography (HPLC) method was developed to analyze key compounds in Shengjiang Powder (SJP), like emodin and curcumin, and assess their effects on experimental autoimmune encephalomyelitis (EAE) in mice.
- A total of 72 SPF C57 BL/6 female mice were assigned to different groups, including a control, model, various SJP dose groups, and a positive control, to study the therapeutic impacts of SJP following EAE induction.
- The study found that SJP improved clinical symptoms, reduced inflammation and demyelination in brain tissues, while also increasing the expression of important proteins and cytokines involved in the JAK2/STAT3 signaling pathway.
Modern pharmacological studies have shown that emodin, the main effective component of rhubarb, has good anti-inflammatory and antioxidant effects, but its pharmacodynamic mechanism remains unclear yet. This study aims to elucidate the multitarget action mechanism of emodin in ischemic stroke through network pharmacology and experiments. Sprague-Dawley rats were randomly divided into control (normal saline), sham (normal saline), model (normal saline), and emodin groups ( = 9 per group).
View Article and Find Full Text PDFArticle Synopsis
- Experimental autoimmune encephalomyelitis (EAE) is a model for studying multiple sclerosis and is marked by damage to the central nervous system due to demyelination.
- Emodin, a compound known for its anti-inflammatory and immunomodulatory properties, was tested for its protective effects against EAE by observing its impact on microglia activation and inflammation in mice.
- Results indicated that high-dose emodin improved symptoms and reduced inflammatory responses through the Myd88/PI3K/Akt/NF-κB signaling pathway, suggesting its potential as a treatment for EAE and multiple sclerosis.
Aim: Ligature tightness of chronic constriction injury (CCI) model remains inconsistent and controversial, presenting barriers for researchers.
Methods: We summarized the different ligation criteria in literature and attempted to clarify their effects. To assess constriction under different criteria, we calculated the radial strain (ε) of ligated nerves from digital photographs.