MRD in Philadelphia Chromosome-Positive ALL: Methodologies and Clinical Implications.

Purpose Of Review: Measurable residual disease (MRD) is integral in the management of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). This review discusses the current methods used to evaluate MRD as well as the interpretation, significance, and incorporation of MRD in current practice.

Recent Findings: New molecular technologies have allowed the detection of MRD to levels as low as 10.

Does de-implementation of low value care impact the patient-clinician relationship? A mixed methods study.

Context: In the U.S., provision of LVC is prevalent (up to 20% of total health services), costly ($350 billion annually), and associated with patient harm.

Does de-implementation of low-value care impact the patient-clinician relationship? A mixed methods study.

Background: The importance of reducing low-value care (LVC) is increasingly recognized, but the impact of de-implementation on the patient-clinician relationship is not well understood. This mixed-methods study explored the impact of LVC de-implementation on the patient-clinician relationship.

Methods: Adult primary care patients from a large Virginia health system volunteered to participate in a survey (n = 232) or interview (n = 24).

Risk Factors for Norovirus Gastroenteritis among Nicaraguan Children.

Norovirus is a leading cause of pediatric gastroenteritis. Understanding norovirus epidemiology is essential for reducing disease burden. We conducted a case-control study to describe the distribution, clinical features, and risk factors of norovirus gastroenteritis among children < 5 years of age in León, Nicaragua.

Harnessing Nature's Diversity: Discovering organophosphate bioscavenger characteristics among low molecular weight proteins.

Organophosphate poisoning can occur from exposure to agricultural pesticides or chemical weapons. This exposure inhibits acetylcholinesterase resulting in increased acetylcholine levels within the synaptic cleft causing loss of muscle control, seizures, and death. Mitigating the effects of organophosphates in our bodies is critical and yet an unsolved challenge.