Publications by authors named "Ken-ichi Tsujii"

Article Synopsis
  • Postprandial hyperlipidemia involves the buildup of chylomicrons and their remnants after eating, which may be linked to cardiovascular diseases, though research is ongoing.
  • A study enrolled 189 patients undergoing coronary angiography to investigate the relationship between chylomicron remnants and coronary artery disease (CAD), focusing on biochemical markers of lipid metabolism.
  • Results showed that fasting serum apo B-48 levels were significantly higher in CAD patients compared to non-CAD subjects, indicating that elevated apo B-48, especially when combined with other risk factors, is associated with a higher prevalence of CAD.
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Plasma high density lipoprotein (HDL)-cholesterol levels are negatively correlated with the incidence of coronary artery disease. HDL plays an important role in protecting against atherosclerosis by removing cholesterol from atheroma and transporting it back to the liver. The ATP-binding cassette transporters (ABCA1 and ABCG1) and scavenger receptor BI (SR-BI) are thought to be one of the rate-limiting factors to generate HDL in the liver.

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Tangier disease (TD) is characterized by a deficiency of high density lipoprotein (HDL) in plasma and patients with TD have an increased risk for coronary artery disease (CAD). Recently, we reported that fibroblasts from TD exhibited large and flattened morphology, which is often observed in senescent cells. On the other hand, data have accumulated to show the relationship between cellular senescence and development of atherosclerotic CAD.

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Objective: Scavenger receptor class B type I (SR-BI) is a major receptor for high-density lipoproteins (HDL) in the liver, which is the terminus of reverse cholesterol transport. Overexpression of SR-BI attenuated experimental atherosclerosis in murine models, concomitant with a reduction in plasma HDL-cholesterol levels. Probucol is known to be a potent hypolipidemic drug to regress xanthoma formation and carotid atherosclerosis in conjunction with a marked reduction in HDL-cholesterol levels.

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Article Synopsis
  • A family was identified with a unique form of tendon xanthomatosis, where multiple members developed massive Achilles tendon growths starting around the age of 30.
  • The proband, a 58-year-old man, showed normal low-density lipoprotein receptor activity and had only mild cholesterol elevation, suggesting an unusual disease mechanism.
  • Investigations into the macrophages of the proband revealed reduced cholesterol efflux related to high-density lipoprotein 3, indicating that this might contribute to the development of their condition.
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The reverse cholesterol transport (RCT) is one of the major protective systems against atherosclerosis, in which high-density lipoprotein (HDL) removes cholesterol from lipid-laden cells and delivers it to the liver. Scavenger receptor class B type I (SR-BI) is a HDL receptor in the liver and adrenal glands and is involved in the selective uptake of cholesteryl ester from HDL, which has been extensively, analyzed using rodent models. However, the expression and regulation of the human homologue of this receptor are not known yet.

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ATP-binding cassette transporter-1 (ABCA1) is a cause of Tangier disease, which is a familial deficiency of plasma high density lipoproteins (HDL). This molecule is known to be expressed in the multiple tissues and organs including small intestines, liver, and macrophages in the blood vessels. Recent in vivo studies suggested that ABCA1 plays some roles in the flux of cholesterol in the intestines.

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