Publications by authors named "Ken-ichi Sugiyama"

Article Synopsis
  • Photodynamic therapy (using Photofrin) shows promise as a less invasive treatment for head and neck squamous cell carcinoma, focusing on evaluating its effectiveness in patients.
  • A study involving 42 patients found a 5-year overall survival rate of 57.8%, with a high complete response rate of 69%, highlighting the treatment's potential benefits.
  • Results indicate that earlier tumor stages and certain disease types are linked to better survival outcomes, suggesting the therapy can significantly improve the quality of life for patients with this form of cancer.
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We analyzed 356 patients with idiopathic sudden sensorineural hearing loss treated with hyperbaric oxygen therapy and systemic steroids (n = 161), systemic steroids alone (n = 160), or intratympanic and systemic steroids (n = 35). The main outcome measure was the hearing recovery rate. The effect of other variables, including the initial averaged 5-frequency hearing level, patient age, interval between the onset of symptoms and treatment, presence of vertigo as a complication, presence of diabetes mellitus, smoking history, and presence of hypertension, on the hearing recovery rate was also evaluated.

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We evaluated the outcomes of and prognostic factors for idiopathic sudden sensorineural hearing loss (ISSNHL) treated with adjuvant hyperbaric oxygen therapy (HBOT). A retrospective review of clinical data was performed for 167 patients with ISSNHL who failed to respond to systemic steroids and were treated by adjuvant HBOT at Shizuoka Saiseikai General Hospital. We analysed the clinical outcomes, the averaged 5-frequency hearing level after systemic steroids, patient age, the interval between post-steroids and pre-HBOT, vertigo as a complication, the presence of diabetes mellitus, smoking history, and hypertension.

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In the 20-years from 1991 to 2010, we pathologically diagnosed 24 subjects with parapharyngeal space tumors by biopsying and/or resecting of 24 tumors. Of these, 18 were benign and 6 malignant. Pleomorphic adenoma and schwannoma predominated, accounting for 7 cases each.

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Branchial anomalies are a consequence of abnormal development of the branchial apparatus during embryogenesis. Here, a pediatric case with a right-sided fourth branchial cyst that was discovered on fetal ultrasound scanning (US) is presented. The embryological basis for the occurrence of this cyst and definitive surgical management are discussed.

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The addition of dimethyl phosphonate to six different hexofuranos-5-uloses in the presence of DBU, followed by esterification with methoxalyl chloride and then radical reduction, afforded 5-deoxy-5-dimethoxyphosphinyl-D- and L-hexofuranoses. The stereoselectivity of the deoxygenation and possible transition-state models are discussed.

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