Synopsis of recent research by authors named "Ken-ichi Kudo"
- Ken-ichi Kudo's recent research focuses on the intersection of radiation effects and stem cell biology, exploring mechanisms by which these elements influence cancer development, particularly in mammary cancer models in rats.
- A key finding reveals that continuous low-dose radiation exposure in juvenile rats leads to a reduced incidence of mammary cancer, suggesting that stem/progenitor cells may play a significant role in the dose-rate effect on carcinogenesis.
- Kudo has also investigated the molecular mechanisms behind genomic instability in epithelial stem cells related to the transcriptional repression of p53 target genes by the ΔNp63α variant, indicating its potential role in cancer initiation.
